- Fourth letter of the English Alphabet
- Roman Numeral with the value of 500
- Diploma, e.g. DAC
- Directorate, e.g. DHE
- Distinction
- District, e.g. D4TM
- Grade, usually 1.0
- DC — District Commissioner; Direct current; District of Columbia
- DD — Doctor of Divinity; Double Density
- DNA — Deoxyribonucleic acid
- DND — Do Not Disturb
- DPI — Dots Per Inch
- DPU — Dual Processing Unit
- DQ — Disqualification
- DS — Double Sided; Data Science
- DST — Daylight Savings Time
- DVD — Digital Versatile Disc
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