- Third letter of the English Alphabet
- Roman numeral with the value 100
- Celsius — formerly known as Centigrade
- Central, e.g. CPU (Central Processing Unit)
- Company, e.g. BOC (British Oil Company)
- Computer, e.g. PC (Personal Computer)
- Grade– usually counts as 3.0
- Co — Company
- C/O — Care of)
- Com — Commerce; Company; Communications
- CA — California
- CAD — Computer Aided Design
- CAD — Computer Aided Design
- CB — Chat Box
- CAT — Computerized Axial Tomography
- CG — Center of Gravity
- CO — Commanding Officer; Chief Operator
- CRLF — Carriage Return Line Fee
- CS — Computer Science
- CT — Computer Technology
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